Quantitative Applications of the Networks

Quantitative Applications of the Networks


R. Brett Fields, M.S.

The Quantitative Applications of the Networks Webinar will highlight a novel systems biology-based methodology that leverages the NVC networks and transcriptomic data to quantitatively assess the biological impact of exposures to active substances. The networks provide a coherent framework for investigating the impact of exposures at the molecular, pathway and process levels. A strength algorithm can be used to assign a quantitative score to each mechanism predicted to be active based on transcriptomic data. Scores for each mechanism in a network can then be combined to provide a network score. Finally, multiple network scores can be combined to calculate an overall biological impact factor (BIF) that can then be compared to other treatments, time points or doses in the experiment.
Example scored data sets will be given including in vitro systems with simple exposures, and an in vivo system with a complex exposure. These examples will illustrate that various fields of human disease research, from drug development to consumer product testing and environmental impact analysis, could benefit from using this quantitative network scoring methodology.

About the Speaker

Brett has been a team member at Selventa since June 2012, during which time he served an instrumental role in constructing the series of human biological networks being reviewed during the Network Verification Challenge. During network construction, he contributed extensively to the analysis of lung-specific microarray data sets in the public domain to enhance the networks with features present in Chronic Obstructive Pulmonary Disease (COPD). His scientific expertise in immunology contributed greatly to the refinement of network architecture, particularly related to networks within the inflammation track presented on the NVC website. Brett received his Bachelor of Science (B.S.) degree in Biochemistry from The Georgia Institute of Technology in Atlanta, GA and received a Master of Science (M.S.) degree in Cellular Biology from The Scripps Research Institute in La Jolla, CA.

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